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In addition to its comedolytic, sebum-regulating, and anti-inflammatory properties, it appears capable of inhibiting extracellular matrix metalloproteinases and increasing collagen type I and III production.7 In a prospective study, 20 individuals were administered oral isotretinoin 20mg 3 times a week for 12 weeks

The efficacy evidence is growing: lab studies (AHK-Cu 2007), a 45-patient RCT (Lee/Kim 2016), combination studies (Kuceki 2025), and now this pilot study all point in the same direction

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Low glutathione levels can manifest through symptoms like fatigue, frequent infections, slow recovery from illness, or signs of oxidative stress such as skin issues or inflammation